Central sleep apnea (CSA) is a disorder that affects breathing during sleep. It is distinct from obstructive sleep apnea (OSA), which is much more common and well-known.

CSA is often tied to an underlying health condition, and if it is left unaddressed, it may affect overall health by causing fragmented sleep, daytime drowsiness, thinking problems, moodiness, and fatigue.

While there can be overlap with the causes, symptoms, and treatments of obstructive sleep apnea, central sleep apnea is a distinct disorder, and it is important to understand central sleep apnea in its own right.

What is Central Sleep Apnea?

Central sleep apnea is a condition defined by pauses in breathing due to a lack of respiratory effort during sleep. Unlike obstructive sleep apnea, the pauses in breathing throughout the night are due to the lack of respiratory muscles activating or the brain failing to ask the respiratory muscles to activate.

To breathe in, our brain sends a signal to the diaphragm and the muscles of our rib cage to contract. The contraction of the diaphragm and rib cage muscles produces an inhalation. In central sleep apnea, there is typically a lack of communication from the brain to these muscles.

It is important to note that a few central apneas per night is considered normal. We often “forget to breathe” briefly as we drift off to sleep or after waking up.

How is Central Sleep Apnea Different from Obstructive Sleep Apnea?

In obstructive sleep apnea, a person makes a notable effort to breathe, but the airway in the back of the throat is blocked. The blockage in the back of the throat causes an obstruction to our windpipe, which leads to sleep fragmentation and a disturbed oxygen balance in the body.

In central sleep apnea, the problem isn’t a blocked airway. Instead, pauses in breathing occur because the brain and the muscles that control breathing aren’t functioning properly. As a result, there is no normal respiratory effort, which is in clear contrast to OSA.

While OSA and CSA are separate conditions, they can arise at the same time in what is known as mixed sleep apnea. In addition, treatment of OSA with continuous positive airway pressure (CPAP), can induce central sleep apnea, and this is called treatment-emergent central sleep apnea.

How Common is Central Sleep Apnea?

While the exact number of people with central sleep apnea is unknown, it is estimated that about .9% of people over 40 in the United States have the condition. Though it affects both men and women, it occurs more often in men of greater than 65 years old. People who have a heart condition, use narcotics, suffer from a stroke, live in high altitudes, or use CPAP are at greater risk for central sleep apnea.

What Are the Different Types of Central Sleep Apnea?

Central sleep apnea is divided into two categories, and each of the categories has its subtypes.

The first category we will walk you through is the hypoventilation type. In this type of central sleep apnea, the brain fails to effectively send signals to the respiratory muscle to initiate breathing. Often, carbon dioxide builds up in these cases. Hypoventilation-type of central sleep apnea includes the following subtypes:

Related Reading

The second category of central sleep apnea involves hyperventilation (breathing deep breaths and quickly), followed by pauses in breathing. This type of central sleep apnea occurs because of aberrant pacing and control of respiration. Hyperventilation-type of central sleep apnea includes the following subtypes:

What Are the Symptoms of Central Sleep Apnea?

Most people with central sleep apnea present with disturbed sleep, such as excessive daytime sleepiness, fragmented sleep, waking up feeling unrefreshed, or having morning headaches. As you can imagine, these symptoms are quite non-specific, and one should seek a healthcare professional for further evaluation if these symptoms are present.

In some cases, central sleep apnea can present because a bed partner notices quiet pauses in breathing. In contrast to OSA, snoring is not a common symptom for central sleep apnea.

How is Central Sleep Apnea Diagnosed?

A definitive diagnosis of CSA is made using an in-lab polysomnography, which is a detailed sleep study that measures breathing, respiratory effort, electrocardiogram, heart rate, oxygen, eye movement activity, muscle activity, and electrical activity of the brain during an overnight stay in a sleep clinic.

Because central sleep apnea can be tied to several health problems, a healthcare provider may also recommend other tests, such as a brain scan or an echocardiogram of the heart to determine the underlying cause.

Anyone who has noticed potential symptoms of central sleep apnea should speak with a doctor who can review their situation and determine if any diagnostic testing is appropriate.

What is the Treatment for Central Sleep Apnea?

The key to treating central sleep apnea is addressing any underlying health issues that are causing the condition. The type of treatment for central sleep apnea depends on the category and subtype of central sleep apnea. For example, steps may be taken to mitigate congestive heart failure. Those on opioids or other respiratory-depression medications may gradually reduce and taper off the medications. If at high altitude, the individual can trek back to sea level. In many cases, focusing on the coexisting problem can relieve or eliminate abnormal breathing during sleep.

For many patients with central sleep apnea, the use of CPAP or BiPAP machines can decrease cessations in respiration. Supplemental oxygen may be used in a similar way.

In 2017, the Food and Drug Administration (FDA) approved an implantable device that stimulates breathing-related muscles as a treatment for CSA. This treatment has shown promise in improving breathing and sleep quality in some research studies.

Depending on a person’s situation, a combination of treatments (10) may be used in order to best address their symptoms. A healthcare provider with a specialty in sleep medicine would be best to review the benefits and side effects of various treatment options for central sleep apnea.

+10 Sources

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  3. 3. Nigam G, Riaz M, Chang ET, Camacho M. Natural history of treatment-emergent central sleep apnea on positive airway pressure: A systematic review. Ann Thorac Med. 2018;13(2):86-91.http://doi.org/10.4103/atm.ATM_321_17
  4. 4. Donovan, L. M., & Kapur, V. K. (2016). Prevalence and Characteristics of Central Compared to Obstructive Sleep Apnea: Analyses from the Sleep Heart Health Study Cohort. Sleep, 39(7), 1353–1359.https://doi.org/10.5665/sleep.5962
  5. 5. Eckert, D. J., Jordan, A. S., Merchia, P., & Malhotra, A. (2007). Central sleep apnea: Pathophysiology and treatment. Chest, 131(2), 595–607. https://doi.org/10.1378/chest.06.2287
  6. 6. Rudrappa M, Modi P, Bollu PC. Cheyne Stokes Respirations. [Updated 2020 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available https://www.ncbi.nlm.nih.gov/books/NBK448165/
  7. 7. Strohl, K. P. (2019, February). MSD Manual Professional Version: Central Sleep Apnea. Retrieved July 28, 2020, from https://www.msdmanuals.com/professional/pulmonary-disorders/sleep-apnea/central-sleep-apnea
  8. 8. U.S. Food and Drug Administration (FDA). (2017, October 6). FDA approves implantable device to treat moderate to severe central sleep apnea. Retrieved July 28, 2020, from https://www.fda.gov/news-events/press-announcements/fda-approves-implantable-device-treat-moderate-severe-central-sleep-apnea
  9. 9. Jagielski, D., Ponikowski, P., Augostini, R., Kolodziej, A., Khayat, R., & Abraham, W. T. (2016). Transvenous stimulation of the phrenic nerve for the treatment of central sleep apnoea: 12 months’ experience with the remedē® System. European journal of heart failure, 18(11), 1386–1393.https://doi.org/10.1002/ejhf.593
  10. 10. National Institute of Neurological Disorders and Stroke (NINDS). (2019, March 27). Sleep Apnea Information Page. Retrieved July 28, 2020, from https://www.ninds.nih.gov/Disorders/All-Disorders/Sleep-Apnea-Information-Page

This content was originally published here.

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